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Nanotechnology refers broadly to a field of applied science and technology whose unifying theme is the control of matter on the molecular level in scales smaller than 1 micrometre, normally 1 to 100 nanometers, and the fabrication of devices within that size range.

It is a highly multidisciplinary field, drawing from fields such as applied physics, materials science, colloidal science, device physics, supramolecular chemistry, and even mechanical and electrical engineering. Much speculation exists as to what new science and technology may result from these lines of research. Nanotechnology can be seen as an extension of existing sciences into the nanoscale, or as a recasting of existing sciences using a newer, more modern term.

Two main approaches are used in nanotechnology. In the "bottom-up" approach, materials and devices are built from molecular components which assemble themselves chemically by principles of molecular recognition. In the "top-down" approach, nano-objects are constructed from larger entities without atomic-level control. The impetus for nanotechnology comes from a renewed interest in colloidal science, coupled with a new generation of analytical tools such as the atomic force microscope (AFM), and the scanning tunneling microscope (STM). Combined with refined processes such as electron beam lithography and molecular beam epitaxy, these instruments allow the deliberate manipulation of nanostructures, and led to the observation of novel phenomena.

Examples of nanotechnology in modern use are the manufacture of polymers based on molecular structure, and the design of computer chip layouts based on surface science. Despite the great promise of numerous nanotechnologies such as quantum dots and nanotubes, real commercial applications have mainly used the advantages of colloidal nanoparticles in bulk form, such as suntan lotion, cosmetics, protective coatings, and stain resistant clothing.

Current Research

As nanotechnology is a very broad term, there are many disparate but sometimes overlapping subfields that could fall under its umbrella. The following avenues of research could be considered subfields of nanotechnology. Note that these categories are fairly nebulous and a single subfield may overlap many of them, especially as the field of nanotechnology continues to mature.


This includes subfields which develop or study materials having unique properties arising from their nanoscale dimensions.

  • Colloid science has given rise to many materials which may be useful in nanotechnology, such as carbon nanotubes and other fullerenes, and various nanoparticles and nanorods.
  • Nanoscale materials can also be used for bulk applications; most present commercial applications of nanotechnology are of this flavor.
  • Progress has been made in using these materials for medical applications; see Nanomedicine.

Bottom-up Approaches
These seek to arrange smaller components into more complex assemblies.

  • DNA Nanotechnology utilises the specificity of Watson-Crick basepairing to construct well-defined structures out of DNA and other nucleic acids.
  • More generally, molecular self-assembly seeks to use concepts of supramolecular chemistry, and molecular recognition in particular, to cause single-molecule components to automatically arrange themselves into some useful conformation.

Top-down Approaches
These seek to create smaller devices by using larger ones to direct their assembly.

  • Many technologies descended from conventional solid-state silicon methods for fabricating microprocessors are now capable of creating features smaller than 100 nm, falling under the definition of nanotechnology. Giant magnetoresistance-based hard drives already on the market fit this description, [2] as do atomic layer deposition (ALD) techniques.
  • Solid-state techniques can also be used to create devices known as nanoelectromechanical systems or NEMS, which are related to microelectromechanical systems or MEMS.
  • Atomic force microscope tips can be used as a nanoscale "write head" to deposit a chemical on a surface in a desired pattern in a process called dip pen nanolithography. This fits into the larger subfield of nanolithography.

Functional Approaches
These seek to develop components of a desired functionality without regard to how they might be assembled.

  • Molecular electronics seeks to develop molecules with useful electronic properties. These could then be used as single-molecule components in a nanoelectronic device. For an example see rotaxane.
  • Synthetic chemical methods can also be used to create synthetic molecular motors, such as in a so-called nanocar.

These subfields seek to anticipate what inventions nanotechnology might yield, or attempt to propose an agenda along which inquiry might progress. These often take a big-picture view of nanotechnology, with more emphasis on its societal implications than the details of how such inventions could actually be created.

  • Molecular nanotechnology is a proposed approach which involves manipulating single molecules in finely controlled, deterministic ways. This is more theoretical than the other subfields and is beyond current capabilities.
  • Nanorobotics centers on self-sufficient machines of some functionality operating at the nanoscale. There are hopes for applying nanorobots in medicine, but it may not be easy to do such a thing because of several drawbacks of such devices. Nevertheless, progress on innovative materials and methodologies has been demonstrated with some patents granted about new nanomanufacturing devices for future commercial applications, which also progressively helps in the development towards nanorobots with the use of embedded nanobioelectronics concept.
  • Programmable matter based on artificial atoms seeks to design materials whose properties can be easily and reversibly externally controlled.
  • Due to the popularity and media exposure of the term nanotechnology, the words picotechnology and femtotechnology have been coined in analogy to it, although these are only used rarely and informally.

Although there has been much hype about the potential applications of nanotechnology, most current commercialized applications are limited to the use of "first generation" passive nanomaterials. These include titanium dioxide nanoparticles in sunscreen, cosmetics and some food products; silver nanoparticles in food packaging, clothing, disinfectants and household appliances; zinc oxide nanoparticles in sunscreens and cosmetics, surface coatings, paints and outdoor furniture varnishes; and cerium oxide nanoparticles as a fuel catalyst. The Woodrow Wilson Center for International Scholars' Project on Emerging Nanotechnologies hosts an inventory of consumer products which now contain nanomaterials.

However, further applications which require actual manipulation or arrangement of nanoscale components await further research. Though technologies currently branded with the term 'nano' are sometimes little related to and fall far short of the most ambitious and transformative technological goals of the sort in molecular manufacturing proposals, the term still connotes such ideas. Thus there may be a danger that a "nano bubble" will form, or is forming already, from the use of the term by scientists and entrepreneurs to garner funding, regardless of interest in the transformative possibilities of more ambitious and far-sighted work.

The National Science Foundation (a major source of funding for nanotechnology in the United States) funded researcher David Berube to study the field of nanotechnology. His findings are published in the monograph “Nano-Hype: The Truth Behind the Nanotechnology Buzz". This published study (with a foreword by Anwar Mikhail, Senior Advisor for Nanotechnology at the National Science Foundation) concludes that much of what is sold as “nanotechnology” is in fact a recasting of straightforward materials science, which is leading to a “nanotech industry built solely on selling nanotubes, nanowires, and the like” which will “end up with a few suppliers selling low margin products in huge volumes."

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